Can Influenza Vaccination Protect Against Alzheimer’s Disease?

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An early on-line model of the paper detailing the findings is out there earlier than its publication within the Aug. 2 subject of the

“We found that flu vaccination in older adults reduces the risk of developing Alzheimer’s disease for several years. The strength of this protective effect increased with the number of years that a person received an annual flu vaccine – in other words, the rate of developing Alzheimer’s was lowest among those who consistently received the flu vaccine every year,” stated Bukhbinder, who remains to be a part of Schulz’s analysis crew whereas in his first yr of residency with the Division of Little one Neurology at Massachusetts Common Hospital. “Future research should assess whether flu vaccination is also associated with the rate of symptom progression in patients who already have Alzheimer’s dementia.”

Flu Vaccination Decreases Alzheimer’s Illness Danger

The examine – two years after UTHealth Houston researchers discovered a doable hyperlink between the flu vaccine and lowered danger of Alzheimer’s illness – analyzed a a lot bigger pattern than earlier analysis, together with 935,887 flu-vaccinated sufferers and 935,887 non-vaccinated sufferers.

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Throughout four-year follow-up appointments, about 5.1% of flu-vaccinated sufferers have been discovered to have developed Alzheimer’s illness. In the meantime, 8.5% of non-vaccinated sufferers had developed Alzheimer’s illness throughout follow-up.

“Since there is evidence that several vaccines may protect from Alzheimer’s disease, we are thinking that it isn’t a specific effect of the flu vaccine,” stated Schulz, who can be the Umphrey Household Professor in Neurodegenerative Illnesses and director of the Neurocognitive Problems Heart at McGovern Medical Faculty.

“Instead, we believe that the immune system is complex, and some alterations, such as pneumonia, may activate it in a way that makes Alzheimer’s disease worse. But other things that activate the immune system may do so in a different way — one that protects from Alzheimer’s disease. Clearly, we have more to learn about how the immune system worsens or improves outcomes in this disease.”

Alzheimer’s illness impacts greater than 6 million individuals residing within the U.S., with the variety of affected people rising as a result of nation’s growing older inhabitants. Previous research have discovered a decreased danger of dementia related to prior publicity to numerous maturity vaccinations, together with these for tetanus, polio, and herpes, along with the flu vaccine and others.

Moreover, as extra time passes for the reason that introduction of the COVID-19 vaccine and longer follow-up knowledge change into out there, Bukhbinder stated it could be price investigating whether or not the same affiliation exists between COVID-19 vaccination and the chance of Alzheimer’s illness.

Supply: Eurekalert

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