How to Treat COVID-19 Pneumonia in Pregnant Women?

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Pneumonia triggered by COVID-19 is especially threatening to pregnant girls since it might rapidly progress to oxygen insufficiency within the blood and bodily tissues, a situation often known as hypoxemia, requiring hospitalization and cardiopulmonary help. “Compared to non-pregnant female patients with COVID-19, pregnant women are three times more likely to need intensive care unit admission, mechanical ventilation, or advanced life support, and four times more likely to die,” notes Carlo Valsecchi, MD, lead creator within the Division of Anesthesia, Essential Care and Ache Drugs, MGH. “They also face a greater risk of obstetric complications such as preeclampsia, preterm delivery, and stillbirth.”

Nitric oxide is a therapeutic gasoline that was initially permitted by the U.S. Meals and Drug Administration in 1999 for inhalation remedy of intubated and mechanically ventilated newborns with hypoxic respiratory failure. With MGH driving many early research, iNO in excessive concentrations was additionally proven to be efficient as an antimicrobial in decreasing viral replication of SARS-CoV-1 and, extra just lately, SARS Co-V-2, the virus that causes COVID-19. Through the first wave of COVID-19, MGH handled six non-intubated pregnant sufferers with iNO at excessive doses of as much as 200 components per million (ppm). Findings of a extra favorable consequence with iNO led MGH clinicians to supply this remedy to different pregnant sufferers, and to design the present examine to find out the security and efficacy of iNO200 for COVID-19 pneumonia in being pregnant.

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To that finish, a collaborative community of 4 medical facilities within the Boston space was fashioned. Along with MGH, it included Tufts Medical Heart, Beth Israel Deaconess Medical Heart, and Boston Medical Heart. Researchers and clinicians from a number of departments — together with essential care drugs, respiratory care, and maternal fetal drugs — studied 71 pregnant sufferers with extreme COVID-19 pneumonia admitted to those hospitals, 20 of whom acquired iNO200 twice every day. The examine discovered that iNO remedy at this dosage, when in comparison with customary of care alone, resulted in reductions within the want for supplemental oxygen and in hospital and ICU lengths of keep. No opposed occasions associated to the intervention have been reported in both moms or their infants.

“Being able to wean patients from respiratory support quicker could have other profound implications, including reducing stress on women and their families, lowering the risk of hospital-acquired infections, and relieving the burden on the health care system,” notes Berra. “Above all, our study supports the safety of high dose nitric oxide in the pregnant population, and we hope more physicians will consider incorporating it into carefully monitored treatment regimens.”

Supply: Eurekalert

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