Researchers from Ben-Gurion College of the Negev determined to go in a unique course and investigated a phytochemical derived from cruciferous greens similar to broccoli that breaks down the biofilm.
The phytochemical 3,3′-diindolylmethane (DIM) efficiently broke down the biofilms defending two completely different pathogens together with Acinetobacter baumannii and Pseudomonas aeruginosa– enabling their eradication 65% and 70% of the time, respectively. Mixed with antibiotics, that quantity jumped to 94%.
Prof. Ariel Kushmaro, Dr. Karina Golberg and his group along with Prof. Robert Marks, all of them members of the Avram and Stella Goldstein-Goren Division of Biotechnology Engineering at BGU chronicled their findings within the peer-reviewed journal Pharmaceutics just lately.
Moreover, after they launched DIM into an contaminated wound, it sped up the therapeutic course of considerably, the group discovered.
“Our findings show promise for other avenues of research in addition to known classes of antibiotics,” says Prof. Kushmaro.
Additional growth and commercialization of the know-how is presently being carried out on the startup firm LifeMatters.
Further researchers from Prof. Kushmaro’s lab included: Bat-el Kagan, Sigalit Barzanizan, Dr. Karin Yaniv and Dr. Esti Kramarsky-Winter. They collaborated with researchers from Close to East College and Girne American College in Cyprus.
The analysis was supported by the Nationwide Institute for Biotechnology within the Negev and Israel’s Ministry of Science and Know-how.
Prof. Kushmaro can be a member of the Goldman Sonnenfeldt College of Sustainability and Local weather Change, and the Ilse Katz Middle for Nanoscale Science and Know-how.